Yes, of course. I know quite a few.
However, you need a job offer, and that usually means acquiring special qualifications. I know some people who were living abroad as students -- usually graduate students working on a dissertation -- who were offered jobs while abroad on student visas, but some people I know working abroad started out working here in the US and were eventually transferred abroad by a multinational employer.
You really can't just move overseas and hope to find a good job once you get there. Employers abroad hire their own first, and you'd need qualifications they couldn't find in their own fellow citizens. That's why most of the people I know who are living and working abroad are academics and specialists in pretty narrow scholarly areas, or else highly-trained specialists in their areas of business.