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Does anyone know anything about Hyperalgesia!?

I have a few questions. I know a bit about it but would love more in-depth detail.

1- what actually is it?

2-how does it Happen?

3- how to know for sure it’s definitely that and not just actual pain? 

3- can you reverse it? If so how? And how long does it take? 

4- and could you ever take painkillers again in the future and not get Hyperalgesia again? (if there is a way to cure it) 

3 Answers

  • ?
    Lv 7
    2 months ago
    Favourite answer

    1] Hyperalgesia is a phenomenon in which a person has a heightened sensitivity and severity to pain.  Because pain is a subjective experience, it's somewhat difficult to quantify and study.

    2] It's believed to be caused by up-regulation of mu receptors, which are the nerve sensing apparatus that transmits "pain" signals to the central nervous system.  The body frequently up or down regulate things in response to medications.  Most often it occurs when a person takes opiates.  Opiates block mu receptors and in response to them being blocked, the body causes an increase in the receptor.  The effect, then, is that the person is always in pain when they don't have the opiate to block receptors and they require more and more opiates to achieve the same analgesic effect.

    3] It is actual pain, but the experience is exaggerated.  The way one can determine, is to have medical experience and see that the patient's pain is out of proportion to the thing that's causing it.

    4] After discontinuing opiate medication, the nervous system does down-regulate mu receptors and the condition resolves, to an extent.  Such a person will likely never return to their "normal" pain response, but it can get better to such a point that they can live without symptoms.    Those who have prior chemical dependency are at greater risk for recurrence even with careful and appropriate administration of the offending drug[s], so clinicians have to weigh the risk vs benefit of giving those medications when the patient has such a history.

  • Andy C
    Lv 7
    1 month ago

    Nerves are a tricky bunch...

  • ?
    Lv 7
    2 months ago

    Google the question to find out.

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